NLE Psychiatric Disorders — Substance Use and Addictive DisordersCheat Sheet
One-page cheat sheet for NLE Psychiatric Disorders — Substance Use and Addictive Disorders. Every formula, definition, and key fact you need for this chapter, condensed to a single printable page. Designed for the final review session before the NLE 2026.
Exam context
For the Philippine Nurse Licensure Examination (PNLE), Professional Regulation Commission (PRC) — Board of Nursing tests Psychiatric Disorders under a "Core" label, with Substance Use and Addictive Disorders in the 5th slot across 7 chapters. NLE candidates must clear the 75% weighted average with no sub-test below 60% cut on the 2026 paper, which draws about 50 Psychiatric Disorders questions. Date to watch: Bi-annual.
Substance Use and Addictive Disorders - Cheat Sheet
Your last-minute rapid-fire reference for alcohol, opioid, stimulant, and sedative-hypnotic disorders, withdrawal timelines, pharmacology, RA 9165, and nursing priorities. Review in the final 30 minutes before your NLE psychiatric nursing section.
Sections
Section Title
Core Terminology & Definitions
Important Facts
- Tolerance ≠ Dependence ≠ Addiction — three distinct concepts.
- Physical dependence can occur with appropriate medication use (e.g., prescribed opioids).
- Withdrawal is a medical emergency when life-threatening (alcohol, sedatives, barbiturates).
- Not all substances produce dangerous withdrawal (e.g., cocaine and marijuana withdrawal are uncomfortable but not lethal).
- Addiction is a psychiatric disorder with behavioral hallmarks, not purely a pharmacologic phenomenon.
Key Definitions
Term
Tolerance
Example
Chronic drinker needs 10 beers instead of 2 to feel drunk.
Definition
Physiologic adaptation requiring increased doses for same effect; NOT addiction.
Term
Physical Dependence
Example
Patient on prescribed morphine develops withdrawal if stopped abruptly.
Definition
Body adapted; withdrawal syndrome appears on cessation; does NOT equal addiction.
Term
Addiction (Substance Use Disorder)
Example
Patient drinks despite losing job, family, and health.
Definition
Behavioral pattern of compulsive use, craving, and continued use despite harm; psychological/behavioral, distinct from tolerance and dependence.
Term
Withdrawal
Example
Tremors, anxiety, sweating 6–12 hours after last alcoholic drink.
Definition
Cluster of signs/symptoms appearing when substance reduced/stopped after chronic use.
Term
Intoxication
Example
Slurred speech and incoordination after alcohol; dilated pupils after cocaine.
Definition
Reversible, substance-specific syndrome from recent use; CNS effects depend on substance class.
Term
Codependency
Example
Spouse covers addict's lies or pays bills to prevent consequences.
Definition
Enabling relationship pattern in family members supporting continued use.
Term
Dual Diagnosis
Example
Patient with alcohol use disorder AND major depressive disorder.
Definition
Concurrent substance use disorder and another psychiatric illness (depression, bipolar, psychosis).
Diagrams To Know
- Distinction between tolerance, dependence, and addiction
- Spectrum from casual use to substance use disorder
Common Values
Value
6–12 hours
Symbol
t₁
Quantity
Onset of early withdrawal
Value
12–24 hours
Symbol
t₂
Quantity
Onset of alcoholic hallucinosis
Value
24–48 hours
Symbol
t₃
Quantity
Onset of withdrawal seizures
Value
48–72 hours
Symbol
t₄
Quantity
Peak of delirium tremens
Section Title
Alcohol Use Disorder: Intoxication & Withdrawal
Important Facts
- Alcohol is a CNS DEPRESSANT; withdrawal produces CNS excitation/rebound hyperactivity.
- Early withdrawal (tremors, anxiety) starts 6–12 hours after last drink.
- Alcoholic hallucinosis (visual/tactile hallucinations with clear sensorium) appears at 12–24 hours.
- Withdrawal seizures occur at 24–48 hours.
- Delirium tremens peaks at 48–72 hours and is MEDICAL EMERGENCY (mortality ~5–15% if untreated).
- Autonomic signs in DTs: severe tachycardia, hypertension, hyperthermia (up to 41°C), profuse diaphoresis.
- DTs priority nursing: safe environment, frequent vital signs, benzodiazepines, seizure precautions.
- ALWAYS give thiamine BEFORE glucose in alcoholic patients to prevent Wernicke's.
- Wernicke's is REVERSIBLE if treated quickly; Korsakoff's is largely IRREVERSIBLE.
- Malnutrition and thiamine deficiency are core to understanding alcohol-related brain syndromes.
Key Definitions
Term
Alcohol Intoxication
Example
Patient smells of alcohol, is unsteady, and cannot speak clearly.
Definition
CNS depression causing slurred speech, incoordination, nystagmus, impaired judgment; severe cases → respiratory depression, stupor, coma.
Term
Delirium Tremens (DTs)
Example
Patient sees bugs crawling on skin (tactile), is disoriented to person/place/time, HR 130, temp 39.5°C, profusely diaphoretic.
Definition
Most severe form of alcohol withdrawal; severe autonomic hyperactivity + profound confusion + vivid (often terrifying) hallucinations.
Term
Wernicke's Encephalopathy
Example
Patient cannot move eyes laterally, staggers, and is confused; treated urgently with IV thiamine.
Definition
Acute, reversible thiamine deficiency syndrome with classic triad: confusion, ophthalmoplegia (eye abnormalities), ataxia.
Term
Korsakoff's Syndrome
Example
Patient cannot remember breakfast but invents stories about events that didn't happen.
Definition
Chronic, largely irreversible form; profound short-term memory loss + confabulation to fill gaps.
Diagrams To Know
- Alcohol withdrawal timeline with onset times for tremors, hallucinosis, seizures, and DTs
- Pathophysiology of Wernicke–Korsakoff syndrome
- Autonomic signs progression in delirium tremens
Common Values
Value
< 10
Symbol
Score
Quantity
CIWA-Ar mild withdrawal
Value
10–20
Symbol
Score
Quantity
CIWA-Ar moderate withdrawal
Value
> 20
Symbol
Score
Quantity
CIWA-Ar severe withdrawal
Section Title
Alcohol Withdrawal: Pharmacology & CIWA Assessment
Important Facts
- Benzodiazepines are FIRST-LINE and DRUG-OF-CHOICE for alcohol withdrawal and DTs.
- Lorazepam preferred over diazepam if liver dysfunction present.
- ALWAYS give thiamine BEFORE glucose — critical to prevent Wernicke's encephalopathy.
- Symptom-triggered dosing with CIWA-Ar is preferred over fixed schedules — reduces benzodiazepine overuse.
- Magnesium replacement important; hypomagnesemia lowers seizure threshold.
- Folic acid and multivitamins routinely added to address malnutrition.
- Monitor for benzodiazepine oversedation and respiratory depression.
- Avoid abrupt benzodiazepine discontinuation — taper gradually.
- CIWA-Ar assessment done at regular intervals (e.g., every 1–4 hours) to guide medication adjustments.
Key Definitions
Term
Benzodiazepines (First-line for alcohol withdrawal)
Example
Lorazepam 2 mg IV q4h symptom-triggered based on CIWA score; preferred over diazepam if liver impaired.
Definition
CNS depressants that mimic alcohol's depressant effect; generic names: diazepam, lorazepam, chlordiazepoxide; tapered gradually.
Term
Thiamine (Vitamin B1)
Example
100 mg IV/IM thiamine before starting 5% dextrose IV to prevent precipitating Wernicke's.
Definition
Essential cofactor for glucose metabolism; deficiency causes Wernicke–Korsakoff; given IV/IM BEFORE or WITH glucose.
Term
Symptom-Triggered Dosing (CIWA-Ar based)
Example
If CIWA-Ar = 8, give lorazepam; if CIWA-Ar = 18, give higher dose. Prevents overmedication.
Definition
Benzodiazepine dosing given based on withdrawal severity score, not fixed schedule; reduces over- and under-treatment.
Term
CIWA-Ar (Clinical Institute Withdrawal Assessment—Alcohol revised)
Example
Items: nausea/vomiting, tremor, sweating, anxiety, agitation, tactile/auditory/visual disturbances, headache, orientation.
Definition
10-item validated scale quantifying alcohol withdrawal severity; ranges 0–67; higher = more severe.
Diagrams To Know
- CIWA-Ar scoring components and severity interpretation
- Benzodiazepine dosing algorithm based on CIWA score
Common Values
Value
~2 weeks
Symbol
t
Quantity
Duration of disulfiram effect after last dose
Section Title
Disulfiram (Antabuse): Aversion Therapy
Important Facts
- Disulfiram BLOCKS alcohol metabolism, not alcohol consumption — patient must ABSTAIN.
- Requires patient MOTIVATION and INFORMED CONSENT; only works with patient's commitment.
- Must avoid ALL alcohol sources: mouthwash, cough syrups, aftershave, cologne, vinegar, certain foods/sauces, OTC preparations.
- Reaction can occur from topical or inhaled alcohol — educate on ALL hidden sources.
- Reaction lasts as long as drug in system — up to ~2 weeks after stopping disulfiram.
- Disulfiram–alcohol reaction can be SEVERE → cardiovascular collapse in worst cases.
- Nursing teaching CRITICAL: detailed list of hidden alcohol sources and absolute necessity of abstinence.
- Alternative agents: naltrexone and acamprosate (support abstinence and reduce craving without aversion).
Key Definitions
Term
Disulfiram (Antabuse)
Example
Patient on disulfiram takes one sip of beer → severe flushing, throbbing headache, nausea, vomiting, tachycardia, hypotension.
Definition
Aversion-therapy drug blocking alcohol metabolism, causing acetaldehyde accumulation; used for abstinence maintenance.
Term
Disulfiram–Alcohol Reaction
Example
Patient uses mouthwash containing alcohol while on disulfiram → systemic reaction; severe cases → cardiovascular collapse.
Definition
Severe, unpleasant reaction from alcohol consumption while on disulfiram; includes flushing, headache, nausea, vomiting, tachycardia, hypotension.
Diagrams To Know
- Disulfiram mechanism: alcohol → inhibition of acetaldehyde dehydrogenase → acetaldehyde accumulation
- Timeline of disulfiram–alcohol reaction onset and duration
Common Values
Value
15–90 minutes
Symbol
t
Quantity
Naloxone duration of action
Value
3–5 hours
Symbol
t
Quantity
Heroin duration of action
Section Title
Opioid Use Disorder
Important Facts
- Opioid overdose = PINPOINT PUPILS + RESPIRATORY DEPRESSION + DECREASED LOC — immediate life threat is respiratory arrest.
- Naloxone is SHORT-ACTING (15–90 min); heroin/long-acting opioids last longer → re-sedation and re-dosing needed.
- Naloxone can precipitate ACUTE WITHDRAWAL in opioid-dependent patients.
- Opioid withdrawal uncomfortable but NOT LIFE-THREATENING (unlike alcohol or sedative-hypnotic withdrawal).
- Methadone and buprenorphine are opioid agonists, not antagonists — they substitute for the opioid.
- Buprenorphine is PARTIAL agonist with lower overdose risk than methadone.
- Clonidine helps autonomic symptoms but does NOT reduce craving.
- Opioid withdrawal can be managed with or without medication, but pharmacologic support improves outcomes.
Key Definitions
Term
Opioid Intoxication/Overdose
Example
Patient found unresponsive with pupils like pinheads, barely breathing; immediate risk = respiratory arrest.
Definition
CNS depression with classic triad: pinpoint (constricted) pupils, respiratory depression, decreased level of consciousness.
Term
Naloxone (Narcan)
Example
Patient given naloxone IV, wakes up and breathes; but needs re-dosing q20–60 min because naloxone wears off before heroin.
Definition
Opioid antagonist rapidly reversing respiratory depression in overdose; SHORT-ACTING, so repeat dosing and monitoring for re-sedation essential.
Term
Opioid Withdrawal
Example
Patient sweating, achey, diarrhea, craving; vital signs may be elevated but respiratory depression/seizure risk absent (unlike alcohol/sedative withdrawal).
Definition
Intensely uncomfortable but generally NOT life-threatening; includes dilated pupils, yawning, lacrimation, rhinorrhea, muscle aches, abdominal cramping, diarrhea, piloerection.
Term
Methadone & Buprenorphine
Example
Patient on methadone maintenance avoids illicit opioid use and withdrawal symptoms.
Definition
Long-acting opioid agonists used for medically supervised withdrawal and maintenance; reduce craving and prevent withdrawal.
Term
Clonidine
Example
Reduces sweating, anxiety, and muscle aches during withdrawal but does NOT reduce craving.
Definition
Alpha-2 agonist easing autonomic symptoms of opioid withdrawal without addressing craving.
Diagrams To Know
- Opioid intoxication vs. withdrawal comparison
- Naloxone mechanism and timeline of action
- Methadone and buprenorphine role in maintenance and withdrawal
Common Values
Value
5–30 minutes
Symbol
t
Quantity
Cocaine intoxication duration
Value
8–24 hours
Symbol
t
Quantity
Methamphetamine intoxication duration
Section Title
Stimulant Use Disorder (Cocaine, Amphetamines, Methamphetamine/Shabu)
Important Facts
- Stimulants = CNS EXCITATION; intoxication is opposite of alcohol/opioid intoxication.
- Stimulant intoxication: DILATED pupils (vs. alcohol/opioid = constricted), hypertension, hyperthermia, severe agitation.
- Seizures, dysrhythmias, MI, stroke, and psychosis are acute medical/psychiatric emergencies.
- Management: supportive (calm environment, monitoring), control of hypertension, hyperthermia, agitation; NO specific antagonist.
- Stimulant withdrawal (crash) brings INTENSE depression and suicidality — SUICIDE RISK is key concern.
- Withdrawal not life-threatening physiologically but psychological/psychiatric danger is extreme.
- Methamphetamine ('shabu') abuse prevalent in Philippines; highly addictive, rapid progression to dependence.
- No FDA-approved medication for stimulant withdrawal (unlike opioids); treatment is supportive + psychiatric care.
- Antidepressants may help withdrawal depression; stimulants contraindicated.
Key Definitions
Term
Stimulant Intoxication
Example
Patient agitated, paranoid, believing people are spying; heart racing, temp elevated, sweating; risk of sudden cardiac death or stroke.
Definition
CNS excitation producing euphoria, hypervigilance, dilated pupils, tachycardia, hypertension, hyperthermia, agitation; severe cases → seizures, dysrhythmias, MI, stroke, psychosis with paranoia/hallucinations.
Term
Stimulant Withdrawal (Crash)
Example
After binge use, patient sleeps 18 hours, feels hopeless and worthless, contemplating suicide.
Definition
Intense fatigue, hypersomnia, depression, anhedonia, and craving; NOT life-threatening but suicide risk HIGH.
Term
Methamphetamine (Shabu)
Example
Patient has poor oral hygiene ('meth mouth'), skin picking, paranoia, psychosis; common substance of abuse in PH.
Definition
Highly potent, highly addictive amphetamine derivative; extremely relevant in Philippines; intoxication/withdrawal mirrors cocaine but often more severe/protracted.
Diagrams To Know
- Stimulant intoxication acute effects and medical emergencies
- Stimulant withdrawal timeline and suicide risk window
- Comparison of cocaine vs. methamphetamine intoxication and withdrawal
Common Values
Value
6–100+ hours
Symbol
t₁/₂
Quantity
Benzodiazepine half-life range
Value
Very narrow
Symbol
Ratio
Quantity
Barbiturate therapeutic window
Section Title
Sedative-Hypnotic Use Disorder (Benzodiazepines & Barbiturates)
Important Facts
- Sedatives/hypnotics = CNS depressants; withdrawal mirrors alcohol and is POTENTIALLY FATAL.
- Sedative-hypnotic withdrawal includes seizures and delirium — life-threatening.
- NEVER abruptly stop benzodiazepines or barbiturates in chronic users — must taper gradually under supervision.
- Management of withdrawal: benzodiazepine taper (slowly reduce), reassurance, monitoring for seizures/delirium.
- Flumazenil reverses benzodiazepine overdose but risk of precipitating seizures — use cautiously, monitor closely.
- Barbiturate withdrawal is more dangerous than benzodiazepine withdrawal; narrow therapeutic window.
- Cross-tolerance exists between alcohol, benzodiazepines, and barbiturates — withdrawal management similar.
- Monitor for respiratory depression in intoxication/overdose — may need airway support, supplemental O₂, or mechanical ventilation.
Key Definitions
Term
Sedative-Hypnotic Intoxication
Example
Patient on benzodiazepines appears sedated, uncoordinated, and confused; overdose = respiratory depression risk.
Definition
CNS depression similar to alcohol; drowsiness, slurred speech, incoordination, impaired judgment; severe = respiratory depression, stupor, coma.
Term
Sedative-Hypnotic Withdrawal
Example
Patient on long-term diazepam abruptly stopped; develops tremors at 12 h, seizures at 24 h, delirium at 48 h.
Definition
LIFE-THREATENING and MIRRORS ALCOHOL WITHDRAWAL; tremors, anxiety, seizures, delirium possible; NEVER abruptly stop.
Term
Flumazenil
Example
Patient overdosed on diazepam; flumazenil given IV but carefully monitored for seizure risk.
Definition
Benzodiazepine antagonist reversing benzodiazepine overdose; used cautiously because can precipitate seizures.
Term
Barbiturate Overdose
Example
Barbiturate OD has worse prognosis than benzodiazepine OD due to narrow therapeutic window.
Definition
Especially dangerous; narrow margin between therapeutic and lethal dose; respiratory depression, coma, death.
Diagrams To Know
- Sedative-hypnotic withdrawal timeline and danger signs
- Comparison of alcohol, benzodiazepine, and barbiturate withdrawal
- Flumazenil use indications and contraindications
Section Title
Rehabilitation & Nursing Interventions
Important Facts
- Recovery is a LONG-TERM process spanning detoxification, rehabilitation, and maintenance.
- Detoxification alone is insufficient — high relapse rate without ongoing treatment.
- 12-step programs (AA, NA, Al-Anon) are cornerstone; peer support and community are healing.
- Nursing stance: FIRM, CONSISTENT, NON-JUDGMENTAL; avoid enabling and rescuing.
- Set clear limits, confront denial/rationalization/manipulation, convey acceptance of PERSON (not behavior).
- Encourage responsibility-taking, trigger identification, and healthy coping.
- Family involvement essential; address codependency and enabling patterns.
- Al-Anon teaches families to detach with love and focus on their own recovery.
- Relapse is common; part of recovery journey; does not mean failure.
- Dual diagnosis (substance use + psychiatric illness) requires integrated treatment.
Key Definitions
Term
Detoxification
Example
Patient hospitalized for alcohol withdrawal; given benzodiazepines and thiamine; vital signs and CIWA monitored.
Definition
Medical management of acute withdrawal; goal is safe, supervised cessation with pharmacologic support.
Term
Rehabilitation
Example
Patient attends NA meetings, works with counselor on triggers and coping strategies, rebuilds family relationships.
Definition
Building coping skills, relapse prevention, life restructuring; involves therapy, education, and behavioral change.
Term
Maintenance & Support (12-Step Programs)
Example
Patient 6 months sober attending AA three times weekly, working with sponsor, pursuing Step 5.
Definition
Long-term, self-help approach; AA (Alcoholics Anonymous), NA (Narcotics Anonymous), Al-Anon (for families); emphasis on sponsorship, community, and spiritual growth.
Term
Codependency
Example
Spouse pays addict's debts, makes excuses, accepts lies — prevents addict from facing consequences.
Definition
Family member enables/rescues addict, sacrificing own needs; perpetuates cycle; Al-Anon addresses this.
Term
Enabling Behaviors
Example
Parent pays adult child's rent after eviction for missing payments due to drug use.
Definition
Actions that allow addict to avoid natural consequences of substance use; e.g., bailing out of jail, paying bills.
Diagrams To Know
- Continuum from active use to long-term recovery
- Detoxification → rehabilitation → maintenance timeline
- Enabling vs. healthy family boundary-setting
Section Title
Republic Act 9165: Comprehensive Dangerous Drugs Act of 2002
Important Facts
- RA 9165 is the legal framework governing drug control in Philippines; nurses must know it.
- DDB = policy; PDEA = enforcement — distinct roles.
- RA 9165 recognizes drug dependent as person needing TREATMENT, not only punishment — paradigm shift toward health.
- Voluntary submission program encourages seeking help without fear of prosecution.
- CONFIDENTIALITY of records is legally mandated — nurses must protect patient privacy strictly.
- RA 9165 sets penalties for manufacture, sale, possession, and use of dangerous drugs.
- Mandatory drug testing in specified populations (e.g., sports, military, certain professions).
- Rehabilitation and treatment are integral to RA 9165; funds allocated for programs.
- Nurses participate in screening, health education, treatment, and prevention within RA 9165 framework.
- Nurses must balance confidentiality with mandatory reporting of dangerous activities (e.g., if patient threatens harm).
Key Definitions
Term
RA 9165 (Comprehensive Dangerous Drugs Act of 2002)
Example
Patient with drug dependence can opt for voluntary submission for rehabilitation; records remain confidential under RA 9165.
Definition
Primary Philippine law governing dangerous drugs; established DDB (policy) and PDEA (enforcement); mandates treatment, rehabilitation, and confidentiality of patient records.
Term
Dangerous Drugs Board (DDB)
Example
DDB formulates national drug strategy; directs resources toward treatment vs. enforcement.
Definition
Policymaking body under RA 9165; sets strategy and policy for drug control in Philippines.
Term
Philippine Drug Enforcement Agency (PDEA)
Example
PDEA conducts drug raids and arrests; enforces penalties for manufacture, sale, possession, use.
Definition
Implementing/enforcement agency under RA 9165; investigates, arrests, prosecutes drug crimes.
Term
Voluntary Submission Program
Example
Patient voluntarily presents to drug treatment center; treated as person needing health care, not criminal.
Definition
Option for drug dependents to admit use and seek treatment without criminal penalty.
Term
Confidentiality of Records
Example
Nurse cannot disclose patient's drug history to employer, family, or public without consent.
Definition
RA 9165 mandates strict confidentiality of drug-dependent patient records; protects privacy and encourages seeking help.
Diagrams To Know
- RA 9165 structure: DDB, PDEA, and treatment programs
- Voluntary submission pathway vs. criminal prosecution pathway
- Legal penalties under RA 9165 by offense type
Must Remember
- ALCOHOL WITHDRAWAL TIMELINE: 6–12 h (tremors/anxiety) → 12–24 h (hallucinosis) → 24–48 h (seizures) → 48–72 h (DTs peak). DTs = severe autonomic hyperactivity + confusion + hallucinations = MEDICAL EMERGENCY. Treatment: benzodiazepines (lorazepam/diazepam/chlordiazepoxide), thiamine BEFORE glucose, seizure precautions, safe environment.
- TOLERANCE ≠ DEPENDENCE ≠ ADDICTION: Tolerance = physiologic (need more for same effect). Dependence = withdrawal on stopping (can occur with prescribed meds). Addiction = behavioral (compulsive use despite harm). All three terms are tested; keep them distinct.
- GIVE THIAMINE BEFORE GLUCOSE in ANY alcoholic patient with altered mental status. Glucose without thiamine = precipitating Wernicke's encephalopathy (confusion, ophthalmoplegia, ataxia — REVERSIBLE with prompt thiamine). Korsakoff's = irreversible memory loss.
- CIWA-Ar SCORE DRIVES BENZODIAZEPINE DOSING: Symptom-triggered approach (based on CIWA, not fixed schedule). Higher scores = higher doses. Reduces both under- and over-treatment. CIWA items: nausea, tremor, sweating, anxiety, agitation, tactile/auditory/visual disturbances, headache, orientation.
- OPIOID OVERDOSE = PINPOINT PUPILS + RESPIRATORY DEPRESSION + DECREASED LOC. Antidote: NALOXONE (short-acting, 15–90 min; repeat dosing needed). Opioid withdrawal NOT life-threatening (vs. alcohol/sedatives).
- DISULFIRAM (ANTABUSE): Patient MUST ABSTAIN from ALL alcohol sources (mouthwash, cough syrup, aftershave, cologne, vinegar, certain foods). Alcohol + disulfiram = severe reaction (flushing, headache, vomiting, hypotension, possible cardiovascular collapse). Requires motivation and informed consent.
- STIMULANTS (COCAINE/AMPHETAMINES/SHABU): Dilated pupils, hypertension, hyperthermia, agitation, psychosis in intoxication. Withdrawal = depression, anhedonia, INTENSE CRAVING & SUICIDE RISK (the withdrawal crash). Management: supportive, psychiatric care; NO pharmacologic antagonist.
- SEDATIVE-HYPNOTIC WITHDRAWAL MIRRORS ALCOHOL: Life-threatening (seizures, delirium possible). NEVER abruptly stop benzodiazepines or barbiturates — TAPER GRADUALLY. Same management as alcohol withdrawal (benzodiazepine taper, monitoring). Flumazenil reverses BZ OD but risks seizures (use cautiously).
- NURSING STANCE IN ADDICTION: FIRM, CONSISTENT, NON-JUDGMENTAL. Set clear limits, avoid enabling/rescuing, confront denial/rationalization/manipulation. Encourage responsibility, trigger identification, healthy coping. Involve family; address codependency. Recovery = long-term (detox → rehab → maintenance + 12-step).
- RA 9165 (COMPREHENSIVE DANGEROUS DRUGS ACT 2002): Created DDB (policy) & PDEA (enforcement). Drug dependent = person needing TREATMENT, not only punishment. Voluntary submission program allows seeking help without criminal penalty. CONFIDENTIALITY of patient records is legally mandated. Nurses participate in screening, treatment, prevention, health education within this framework.
Last Minute Tips
- Remember the COMPLETE alcohol withdrawal timeline by numbers: 6–12 h → 12–24 h → 24–48 h → 48–72 h. If an exam question gives timing (e.g., 'patient 36 hours after last drink'), match to the stage (seizure risk window) and corresponding danger/treatment.
- CIWA-Ar is exam gold: Know that it scores 10 items, ranges 0–67, and guides symptom-triggered benzodiazepine dosing. If you see 'CIWA' in a question, think 'benzodiazepine dosing based on score' and 'not fixed schedule.'
- Tolerance + dependence can coexist with appropriate medication use (e.g., prescribed morphine). Addiction is behavioral compulsive use despite harm. If an exam question describes a patient on prescribed opioids developing tolerance and dependence but NOT using illicitly or against medical advice, that is NOT addiction. Don't confuse the terms.
- When you see 'alcoholic patient with altered mental status,' your reflex is 'THIAMINE BEFORE GLUCOSE.' This can appear in scenarios where IV fluids are ordered. Correct answer = give thiamine first/with glucose, NOT glucose alone.
- Disulfiram questions often test hidden alcohol sources (mouthwash, cough syrup, aftershave, vinegar, certain foods/sauces). If an exam asks 'what patient teaching is critical for disulfiram,' the answer includes comprehensive list of hidden alcohol AND the concept that disulfiram is only effective with patient motivation/informed consent.
Comparison Tables
Rows
Values
- Slurred speech, incoordination, impaired judgment, nystagmus
- Pinpoint pupils, respiratory depression, drowsiness
- Drowsiness, slurred speech, incoordination (similar to alcohol)
Property
Intoxication signs
Values
- 6–12 hours (early); tremors, anxiety, sweating
- 6–12 hours; dilated pupils, yawning, aches, diarrhea
- 12–48 hours; tremors, anxiety, agitation, seizure risk
Property
Withdrawal onset
Values
- YES — seizures, DTs, autonomic collapse
- NO — uncomfortable but not lethal (physiologically)
- YES — seizures, delirium (mirrors alcohol)
Property
Withdrawal life-threatening?
Values
- Benzodiazepines, thiamine, gradual taper
- Methadone/buprenorphine, clonidine, supportive
- Benzodiazepine taper (gradual), seizure precautions
Property
Withdrawal treatment
Values
- YES
- NO
- YES
Property
Can abrupt cessation be fatal?
Values
- Seizures, DTs, respiratory depression, aspiration
- Respiratory depression in OD; suicide in withdrawal
- Seizures, respiratory depression, cardiac dysrhythmias
Property
Priority nursing concern
Columns
- Feature
- Alcohol
- Opioids
- Benzodiazepines / Barbiturates
Table Title
Alcohol vs. Other CNS Depressants: Intoxication & Withdrawal Comparison
Rows
Values
- DILATED
- Normal or CONSTRICTED (alcohol/opioids)
Property
Pupil size in intoxication
Values
- Tachycardia, hypertension
- Bradycardia, hypotension (variable)
Property
Heart rate & BP in intoxication
Values
- Agitation, hypervigilance, paranoia, psychosis
- Sedation, impaired judgment, risk-taking
Property
Behavior
Values
- NOT life-threatening physiologically; SUICIDE RISK HIGH (depression/hopelessness)
- Alcohol & sedatives = LIFE-THREATENING (seizures, delirium); Opioids = uncomfortable but not lethal
Property
Withdrawal danger
Values
- Supportive, psychiatric care, antidepressants; NO antagonist
- Benzodiazepines (alcohol, sedatives); methadone/buprenorphine (opioids); thiamine (alcohol)
Property
Withdrawal treatment
Values
- Seizures, dysrhythmias, MI, stroke, psychosis
- Respiratory depression, coma, death
Property
Acute overdose danger
Columns
- Feature
- Stimulants
- CNS Depressants (Alcohol, Opioids, Sedatives)
Table Title
Stimulants (Cocaine / Amphetamines / Shabu) vs. CNS Depressants
Rows
Values
- Need higher doses for same effect
- Physiologic neuroadaptation
- YES — fades if substance stopped
- NO — can occur with prescribed meds
Property
Tolerance
Values
- Body adapted; withdrawal on cessation
- Neuroadaptation to chronic presence
- YES — withdrawal resolves in time
- NO — occurs with appropriate medications
Property
Physical Dependence
Values
- Compulsive use despite harm, craving, loss of control
- Behavioral, psychological; involves reward system dysfunction
- YES — with treatment and abstinence
- YES — this IS addiction
Property
Addiction (SUD)
Columns
- Concept
- Definition
- Mechanism
- Reversible?
- Equals Addiction?
Table Title
Tolerance vs. Dependence vs. Addiction
Rows
Values
- Acute
- Chronic
Property
Phase
Values
- Thiamine deficiency (often precipitated by glucose without thiamine)
- Thiamine deficiency + chronic alcohol damage to brain
Property
Cause
Values
- Confusion, ophthalmoplegia (eye abnormalities), ataxia
- Profound short-term memory loss, confabulation
Property
Classic triad / signs
Values
- Sudden (hours to days)
- Insidious (develops over time)
Property
Onset
Values
- REVERSIBLE if treated promptly with IV thiamine
- Largely IRREVERSIBLE; permanent memory damage
Property
Reversibility
Values
- Excellent with immediate thiamine; poor if delayed
- Poor — memory loss persists even after thiamine
Property
Prognosis
Values
- URGENT IV thiamine BEFORE or WITH glucose
- Long-term supportive care, safety, cognitive rehabilitation
Property
Nursing priority
Columns
- Feature
- Wernicke's Encephalopathy
- Korsakoff's Syndrome
Table Title
Wernicke's vs. Korsakoff's Syndrome
Rows
Values
- Early withdrawal
- Tremors, anxiety, insomnia, nausea, sweating, tachycardia, hypertension
- Mild to moderate
- Monitor vitals, assess CIWA, ensure safety
- Benzodiazepines (lorazepam per CIWA), thiamine, fluids
Property
6–12 hours
Values
- Alcoholic hallucinosis
- Visual/tactile hallucinations, but sensorium clear; patient knows hallucinations not real
- Moderate
- Safe environment, reorientation, close observation
- Benzodiazepines, reassurance, rule out DTs
Property
12–24 hours
Values
- Withdrawal seizures
- Generalized tonic-clonic seizures (usually brief, multiple)
- Moderate to severe
- Seizure precautions, frequent neuro checks, airway protection
- Benzodiazepines, magnesium, seizure protocol
Property
24–48 hours
Values
- Delirium tremens (DTs)
- Severe confusion, hallucinations, autonomic hyperactivity (tachycardia, hypertension, hyperthermia, diaphoresis)
- SEVERE, MEDICAL EMERGENCY
- Safe quiet room, frequent vitals q15–30 min, seizure precautions, ICU often needed
- Benzodiazepines HIGH-dose, thiamine, fluid/electrolyte correction, treat underlying cause
Property
48–72 hours
Columns
- Time After Last Drink
- Withdrawal Stage
- Key Signs
- Severity
- Nursing Priority
- Treatment
Table Title
Alcohol Withdrawal Timeline: Signs & Nursing Priorities
Rows
Values
- Benzodiazepines
- FIRST-LINE for alcohol & sedative-hypnotic withdrawal
- Mimic alcohol/depressant effect; substitute CNS depression, preventing rebound excitation
- Given IV/IM (lorazepam) or PO; symptom-triggered per CIWA; taper gradually; monitor for oversedation, respiratory depression
Property
Lorazepam, diazepam, chlordiazepoxide
Values
- Water-soluble vitamin
- Prevention of Wernicke's; essential cofactor in glucose metabolism
- Replaces deficiency caused by malnutrition; prevents precipitating encephalopathy
- GIVE BEFORE or WITH glucose; IV/IM preferred; 100 mg typical dose; non-toxic in excess
Property
Thiamine (Vitamin B1)
Values
- Mineral supplement
- Lower seizure threshold; replacement reduces seizure risk
- Hypomagnesemia common in chronic alcohol use; repletion essential
- Monitor serum levels; adjust dosing per renal function; watch for hypermagnesemia
Property
Magnesium sulfate
Values
- Alpha-2 agonist
- Ease autonomic symptoms in opioid (and some alcohol) withdrawal
- Reduces noradrenergic overstimulation; eases sweating, anxiety, muscle aches
- Does NOT reduce craving or prevent seizures; monitor BP (can lower it); no respiratory depression risk
Property
Clonidine
Values
- Opioid agonists
- Medically supervised withdrawal and maintenance in opioid use disorder
- Substitute for illicit opioid; long-acting; prevent withdrawal and craving
- Buprenorphine = partial agonist (lower OD risk); must taper gradually; combined with behavioral therapy
Property
Methadone / Buprenorphine
Columns
- Agent
- Class
- Role in Withdrawal
- Mechanism
- Key Nursing Considerations
Table Title
Benzodiazepines vs. Other Withdrawal Management Agents
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